Contents<br>Section I Effect on the Female Reproductive System<br>1. N on traditional Sites of Endocrine Disruption by Chemicals on the Hypothalamus-Pituitary-Gonadal Axis: Interactions with Steroid Membrane Receptors, Monoaminergic Pathways, and Signal Transduction Systems..................................3<br>Peter Thomas ,.. ,<br>2. Diethylstilbestrol (DES) and Environmental Estrogens<br>Influence the Developing Female Reproductive System.............. 39<br>Retha R. Newbold<br>3. Ovotoxic Environmental Chemicals: Indirect Endocrine<br>Disrupters....................................................................................... 57<br>Patricia B. Hoy er<br>4. Dietary Phytoestrogens.................................................................. 89<br>Heather B. Patisaul and Patricia L. Whitten<br>5. Estrogens, Xenoestrogens, and the Development of<br>Neoplasms .................................................................................... 125<br>Ana M. Soto and Carlos Sonnenschein<br>6. Differential Regulation of Gene Expression by Estrogenic Ligands: A Potential Basis for the Toxicity of Environmental Estrogens....................................................................................... 165<br>Salman M. Hyder, John L. Kirkland, David S. Loose-Mitchell, Sari Mäkelä, and George M. Stancel<br>17. 2,3,7,8-letrachlorodibenzo-p-dioxin (TCDD) and Related Environmental Antiestrogens: Characterization and Mechanism of Action.................................................................... 187<br>Stephen H. Safe<br>Section II Effect on the Male Reproductive System<br>8. Endocrine Disruptors and Male Infertility ................................. 225<br>Suresh C. Sikka and Rajesh K. Naz<br> <br>9. Environmental Antiandrogens as Endocrine Disruptors........... 247<br>William R. Kelce and L. Earl Gray, Jr.<br>10. Endocrine Disruptors and Sexual Dysfunction ..........................279 j<br>Suresh C. Sikka and Rajesh K. Naz \<br>I ;<br>11. The Role of Natural and Manmade Estrogens in Prostate j<br>Development.................................................................................307 !<br>Frederick S. vom Saal and Barry G. Timms ,,- ‘<br>’ ı’ ‘o o’ ",A ıHİ ı<br>12. Metal Ions and Prostate Cancer...................................................329 \<br>Shuk-MeiHo ‘ \<br>Index..................................................................................................... 339 ‘<br>