Biointegration of medical implant materials : science and design

Başlık:

Yazar:

Sharma, Chandra P.

ISBN:

9781845699802

Yayın Bilgisi:

Boca Raton : CRC Press ; Oxford : Woodhead, 2010.

Fiziksel Tanım:

1 online resource (xv, 412 pages) : illustrations.

Seriler:

Woodhead publishing in materials

Woodhead Publishing in materials.

Contents:

Cover; Biointegration of medical implant materials: Science and design; Copyright; Contents; Contributor contact details; Preface; 1 Biointegration: an introduction; 1.1 Introduction; 1.2 Biointegration of biomaterials for orthopedics; 1.3 Biointegration of biomaterials for dental applications; 1.4 AlphaCor artificial corneal experience; 1.5 Biointegration and functionality of tissue engineering devices; 1.6 Percutaneous devices; 1.7 Future trends; 1.8 References; Part I Soft tissue biointegration; 2 Biocompatibility of engineered soft tissue created by stem cells; 2.1 Introduction.

2.2 Bone: from tissue to molecular organization2.3 Bone development; 2.4 Bone homeostasis; 2.5 Bone repair after injury; 2.6 Bone and joint disease; 2.7 Current treatment options and total joint replacements; 2.8 Current challenges of titanium implants; 2.9 Current titanium modifications for improved integration; 2.10 Mimicking nature toward achieving titanium 'biointegration': cytokines and implants; 2.11 Growth factor delivery: why is controlled and sustained release important?; 2.12 Future trends; 2.13 Acknowledgements; 2.14 Sources of further information and advice; 2.15 References.

3 Replacement materials for facial reconstruction at the soft tissue- bone interface3.1 Introduction; 3.2 Facial reconstruction; 3.3 Materials used in traditional interfacial repair; 3.4 Surface modification of facial membranes for optimal biointegration; 3.5 Future trends; 3.6 Acknowledgements; 3.7 References; 4 Corneal tissue engineering; 4.1 Introduction; 4.2 Characteristics of the human cornea and its regeneration; 4.3 Special conditions for wound healing and tissue regeneration of the cornea; 4.4 Approaches to corneal tissue engineering; 4.5 Future trends; 4.6 References.

5 Tissue engineering for small-diameter vascular grafts5.1 Introduction; 5.2 Required characteristics of tissue engineered blood vessels; 5.3 Approaches to vascular tissue engineering; 5.4 Future trends; 5.5 Conclusion; 5.6 References; 6 Stem cells for organ regeneration; 6.1 Introduction; 6.2 Basic components of tissue engineering; 6.3 Tissue engineering and stem cells in organ regeneration; 6.4 Conclusions; 6.5 References; Part II Drug delivery; 7 Materials facilitating protein drug delivery and vascularisation; 7.1 Introduction; 7.2 Hydrogel classification.

7.3 Factors influencing protein encapsulation and release7.4 Tissue engineering applications: vascularisation and protein delivery; 7.5 Conclusions; 7.6 Acknowledgements; 7.7 References; 8 Inorganic nanoparticles for targeted drug delivery; 8.1 Introduction; 8.2 Calcium phosphate nanoparticles; 8.3 Gold nanoparticles; 8.4 Iron oxide nanoparticles; 8.5 Conclusion; 8.6 Acknowledgements; 8.7 References; 9 Alginate-based drug delivery devices; 9.1 Introduction; 9.2 Alginate biopolymers; 9.3 Drug delivery using alginate matrices; 9.4 Future trends; 9.5 Acknowledgement; 9.6 References.

Özet:

Biointegration is essential for the successful performance of implanted materials and devices within the human body. With an increasing number and wide range of implant procedures being performed, it is critical that materials scientists and engineers effectively design implant materials which will create a positive biological and mechanical response with the host tissue. Biointegration of medical implant materials provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integration. Part one discusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering and vascular grafts. Part two then reviews particular techniques in drug delivery including inorganic nanoparticles for targeted drug delivery and alginate based drug delivery devices. Part three covers design considerations with coverage of themes such as biocompatibility of materials and its relevance to drug delivery and tissue engineering, mechanisms of failure of medical implants during long term use and rapid prototyping in biomedical engineering. With its distinguished editor and team of international contributors, Biointegration of medical implant materials: science and design is a standard reference for medical materials scientists and engineers in industry and the academic sector. Provides a unique and comprehensive review of recent techniques and research into material and tissue interaction and integrationDiscusses soft tissue biointegration with chapters on the biocompatibility of engineered stem cells, corneal tissue engineering, vascular grafts and replacement materials for facial reconstructionReviews particular techniques in drug delivery featuring inorganic nanoparticles and functionalized nanoparticles for targeted drug delivery.

Yazar Ek Girişi:

Sharma, Chandra P.

Elektronik Erişim:

ScienceDirect http://www.sciencedirect.com/science/book/9781845695095

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